Interventional strategies for pulmonary arterial hypertension: Current perspectives and future directions - PubMed
3 hours ago
- #Pulmonary Arterial Hypertension
- #Cardiovascular Devices
- #Interventional Cardiology
- Pulmonary arterial hypertension (PAH) can lead to right heart failure and death, with many patients not fully responding to pharmacological therapies.
- Interventional strategies such as pulmonary artery denervation (PADN) have shown encouraging improvements in exercise capacity and hemodynamic parameters in trials.
- Balloon atrial septostomy (BAS) serves as a palliative bridge to transplantation in severe cases, with new modifications to prevent spontaneous closure.
- Renal denervation and transcatheter Potts shunts are promising but require further validation through research.
- Catheter-based cell therapies show potential as future alternatives for PAH treatment.
- Mechanical support devices like ECMO and implantable hemodynamic monitors (e.g., CardioMEMS) provide adjunctive benefits in advanced disease.
- Right ventricular assist devices can be used as bridges to transplant or recovery in certain circumstances.
- The review highlights the need for robust randomized controlled trials to validate these emerging interventional strategies in PAH.