Hidden Architecture of Resistance: The Extracellular Matrix in Melanoma's Immune Landscape - PubMed
3 hours ago
- #melanoma
- #immune-microenvironment
- #extracellular-matrix
- Tumor heterogeneity in cutaneous melanoma determines therapy response and involves diverse tumor, immune, and stromal components.
- The tumor immune microenvironment includes cellular elements like fibroblasts and immune cells, and non-cellular factors such as cytokines and the extracellular matrix.
- Extracellular matrix molecules—collagen, fibronectin, laminin, hyaluronic acid, galectin, and matrix metalloproteinases—play critical roles in shaping the melanoma immune landscape.
- ECM physical properties and biological functions regulate cancer-immune cell interactions, impacting melanoma immunity and clinical outcomes.