Polycomb chromatin topology enables long-range enhancer recruitment during craniofacial development - PubMed
3 days ago
- #craniofacial development
- #enhancer recruitment
- #Polycomb chromatin
- Polycomb chromatin topology in mouse cranial neural crest cells enables long-range enhancer recruitment crucial for craniofacial development.
- Polycomb Repressive Complex 2 (PRC2) establishes a chromatin architecture before neural crest migration, maintaining genes poised and connecting promoters with distal tethering elements.
- Deletion of Ezh2 disrupts this topology, leading to improper gene derepression and failure in enhancer recruitment, impairing gene expression and development.
- A distal Polycomb tethering element is essential for Hoxa2 enhancer recruitment across topologically associating domains during activation.
- Polycomb acts as both a transcriptional repressor and a chromatin organizer, facilitating future enhancer contacts to transition from plasticity to precise gene control in face formation.