High Uric Acid Promotes Stem Leydig Cell Senescence by CCDC90B Mediates Mitochondrial Quality Control Imbalance - PubMed
3 hours ago
- #Mitochondrial Dysfunction
- #Hyperuricemia
- #Testosterone Regulation
- Hyperuricemia is linked to low testosterone levels, with stem Leydig cell (SLC) function being key for maintaining testosterone.
- High uric acid (UA) induces senescence in SLCs, mediated by the protein CCDC90B, which accumulates and disrupts mitochondrial quality control via calcium influx.
- AAV8-CCDC90B gene therapy alleviates SLC senescence and restores testosterone levels in organoid and transgenic mouse models.