Astrocytic SCAP deletion ameliorates diabetes-associated cognitive impairment by suppressing microglial neuroinflammation and lipid droplet accumulation via the LCN2-24p3R-mTOR axis - PubMed
4 hours ago
- #cognitive impairment
- #diabetes
- #neuroinflammation
- Astrocytic SCAP deletion improves cognitive impairment in diabetes by reducing neuroinflammation and lipid accumulation via the LCN2-24p3R-mTOR pathway.
- SCAP upregulation in diabetes enhances LCN2 expression through NF-κB, activating microglial inflammation and lipid droplet buildup.
- Targeting mTOR or LCN2 alleviates neuroinflammation, neuronal injury, and cognitive deficits in diabetic mice, suggesting therapeutic potential.