Spatial transcriptomics uncovers the hybrid molecular identity, ciliated phenotype, and immune signature of adenomyosis lesions - PubMed
3 hours ago
- #adenomyosis lesions
- #immune microenvironment
- #spatial transcriptomics
- Adenomyosis is characterized by ectopic endometrial-like tissue in the myometrium, causing debilitating symptoms and limited treatment options.
- Spatial transcriptomics of human uterine biopsies shows adenomyosis lesions have a transcriptomic profile intermediate between endometrium and myometrium, with enhanced epithelial ciliation and altered pathways.
- The lesion transcriptome resembles the endometrial basalis more than the functionalis, featuring enriched olfactory signaling, dysregulated energy metabolism, and an immune microenvironment indicative of chronic inflammation.
- In silico drug screening identified candidate compounds that could reverse the adenomyosis lesion transcriptomic signature.
- These findings provide insights into the molecular identity of adenomyosis and lay groundwork for developing targeted, lesion-specific therapies as alternatives to hysterectomy.