Ketogenic Diet Prevents Obesity-Associated Pancreatic Cancer Independent of Weight Loss and Induces Pancreatic Metabolic Reprogramming - PubMed
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- #Ketogenic Diet
- #Pancreatic Cancer
- #Metabolic Reprogramming
- Ketogenic diet (KD) delays progression of pancreatic ductal adenocarcinoma (PDAC) in obese mouse models, independent of weight loss.
- KD induces pancreatic metabolic reprogramming, enriching pathways for non-glucose energy production.
- In non-obese mice, KD did not show the same preventive effect on PDAC progression.
- Ketone treatment of pancreas-derived organoids replicated some metabolic effects seen in vivo, indicating a direct impact on cancer cells.
- The findings suggest potential for dietary or metabolic interventions to prevent PDAC in high-risk obese populations.