miR-146a is a pleiotropic regulator of motor neuron degeneration - PubMed
3 hours ago
- #neuroinflammation
- #ALS
- #microRNA
- miR-146a is a pleiotropic regulator of motor neuron degeneration in ALS.
- miR-146a is downregulated in diseased motor neurons but upregulated in bulk tissue.
- Genetic deletion of miR-146a extended survival in SOD1G93A mice, with heterozygous animals showing the most benefit.
- This deletion reduced spinal cord gliosis but not motor neuron loss.
- A subset of miR-146a knockout animals developed spontaneous paralysis and motor neuron loss with age.
- The findings highlight the complex role of neuroinflammation in ALS pathogenesis.