Signals from the bone marrow B cell niches shape pre-leukemic fate in a murine model of B cell acute lymphoblastic leukemia - PubMed
3 hours ago
- #bone marrow niche
- #Galectin-1 signaling
- #pre-leukemic fate
- The bone marrow microenvironment influences the fate of pre-leukemic B cells in a murine model of B-ALL.
- Disrupted pre-BCR signaling in pre-leukemic cells changes their fate; blocking the microenvironment's Galectin-1 impairs proliferation and delays leukemia.
- In the absence of Galectin-1, secondary mutations primarily affect IL-7R signaling instead of both IL-7R and pre-BCR pathways.
- Signals from bone marrow niches cooperate with driver mutations to trigger leukemogenesis and determine pre-leukemic B cell outcomes.