The Energetic Costs of Cellular Computation (2012)
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- #cellular computation
- #Berg-Purcell
- #energy cost
- The paper examines the energetic costs of cellular computations, such as determining chemical ligand concentrations.
- It applies Landauer's Principle to show that cellular computations break detailed balance and require energy consumption.
- A two-component network model is used to calculate the relationship between learning about external concentrations and energy use.
- Greater precision in learning (e.g., more accurate concentration estimates) demands higher energy expenditure.
- These energetic costs may constrain cellular network designs, especially in resource-limited environments like bacterial spore germination.