A continuous DNA repairing system for alleviating intervertebral disc degeneration - PubMed
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- #Cellular Senescence
- #Intervertebral Disc Degeneration
- #DNA Repair
- DNA damage-induced senescence-associated secretory phenotype (SASP) is a key factor in intervertebral disc degeneration (IVDD).
- A continuous DNA repair system was developed using bimetallic-curcumin nanozymes (AuCu-Cur) to scavenge ROS and repair DNA via increased NEIL3 glycosylase.
- Human umbilical cord-derived vesicles (hUCMSC-EVs) enhance the bioavailability of AuCu-Cur, promoting DNA replication and tissue repair through the p-JNK pathway.
- The system effectively alleviated IVDD in a rat tail needle puncture model, offering a strategy for reversing DNA damage-induced cellular senescence.