Single-cell and spatial RNA sequencing in prostate cancer - PubMed
3 hours ago
- #single-cell RNA sequencing
- #spatial transcriptomics
- #prostate cancer
- scRNA-seq is essential in prostate biology research, aiding understanding from development to disease progression.
- Reveals insights into prostate diseases, including tumor microenvironment, cellular plasticity, and therapy resistance.
- Identifies complex interactions between epithelial, stromal, and immune subtypes driving disease heterogeneity.
- Spatial transcriptomics complements scRNA-seq by analyzing tumor architecture at single-cell or multi-cell resolution.
- Enables bioinformatic inference of copy number variants for integrated genomic-transcriptomic analysis.
- Understanding heterogeneity could aid patient stratification, biomarker development, and targeted therapies.