NGFR induces melanoma invasion and immunotherapy resistance through myosin light chain 2 modulation - PubMed
3 hours ago
- #melanoma
- #immunotherapy resistance
- #NGFR-MLC2 axis
- NGFR inhibition with THX-B reduces metastasis and restores immunotherapy sensitivity in melanoma.
- NGFR promotes an invasive, ameboid phenotype via RhoA/ROCK-dependent MLC2 phosphorylation and stabilization.
- High NGFR correlates with poor immunotherapy outcomes and is enriched at invasive tumor sites.