RhoA deficiency in chondrocyte inhibits cartilage fibrosis and ameliorates osteoarthritis progression via SOX4/MMP2 axis - PubMed
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- #Cartilage Fibrosis
- #Osteoarthritis
- #RhoA Pathway
- RhoA deficiency in chondrocytes reduces cartilage fibrosis and slows osteoarthritis (OA) progression via the β-catenin/SOX4/MMP2 pathway.
- RHOA is upregulated in fibrocartilage chondrocytes of OA patients; chondrocyte-specific Rhoa knockout in mice alleviates OA symptoms and matrix degradation.
- RhoA drives chondrocyte transition to a fibrotic state through SOX4 and MMP2; overexpression of these genes reverses protective effects in Rhoa-deficient mice.