Genetic associations between post-traumatic stress disorder and REM-sleep behavior disorder - PubMed
3 hours ago
- #Post-traumatic stress disorder
- #REM-sleep behavior disorder
- #Genetic association
- iRBD is often an early indicator of α-synuclein-related neurodegenerative diseases like Parkinson's and dementia with Lewy bodies.
- Clinical observations indicate a higher prevalence of iRBD in individuals with PTSD compared to those without PTSD.
- Genetic analyses, including polygenic risk scores and correlation studies, found a significant association between PTSD and iRBD, but no causal link.
- An exploratory imaging substudy showed consistent results, though the sample size was small (6 iRBD patients with PTSD vs. 32 without).
- Individuals genetically predisposed to PTSD may have an increased risk for developing iRBD, suggesting potential neurodegenerative risks.
- Further research on iRBD in PTSD patients is recommended to better understand and inform neurodegenerative risk assessment.