Canagliflozin attenuates Parkinson's disease and is associated with modulation of gut-inflammasome-brain axis in rats - PubMed
4 hours ago
- #Parkinson's disease
- #Canagliflozin
- #Gut-brain axis
- Canagliflozin (CANA) shows neuroprotective effects in a rat model of Parkinson's disease (PD).
- Treatment with CANA improved motor function, preserved neuronal integrity, and reduced α-synuclein accumulation in rotenone-induced PD rats.
- CANA modulated the gut microbiota, restored gut integrity, decreased LPS leakage, and reduced systemic and central oxidative stress and inflammation.
- The study suggests CANA's neuroprotection is linked to modulation of the gut-inflammasome-brain axis, involving NLRP3 inflammasome suppression.