Electroacupuncture Ameliorates Learning and Memory Deficits in Vascular Cognitive Impairment Rats Through Activation of the Supramammillary Nucleus-Dentate Gyrus Circuit - PubMed
2 hours ago
- #electroacupuncture
- #cognitive impairment
- #neural circuits
- Electroacupuncture (EA) at ST36 improves learning and memory in vascular cognitive impairment (VCI) rats.
- EA enhances synaptic plasticity and increases neuronal activity in the dentate gyrus (DG).
- EA specifically activates glutamatergic neurons in the supramammillary nucleus (SuM), which regulates the DG.
- Chemogenetic inhibition of the SuM-DG circuit blocks the cognitive benefits of EA.
- The study suggests that EA alleviates VCI deficits via the SuMGlu-DG neural circuit.