Novel HLA class I and II insights into the pathogenesis of systemic sclerosis-associated interstitial lung disease - PubMed
3 hours ago
- #SSc-ILD pathogenesis
- #HLA genetics
- #predictive modeling
- Study identified 12 significant associations within HLA class I and II genes in systemic sclerosis-associated interstitial lung disease (SSc-ILD).
- Class I HLA variants remained significant after adjusting for antitopoisomerase autoantibody (ATA) status, suggesting a role for CD8+ T cells in pathogenesis.
- Class II HLA variants lost significance with ATA adjustment, indicating they may be linked through autoantibody pathways.
- A composite score combining genetic, clinical, and demographic variables improved prediction of SSc-ILD risk, with an AUC of 0.754.
- Findings offer new insights into SSc-ILD pathogenesis and potential biomarkers for better patient management.