Acarbose redirects gut microbiome utilization of dietary carbohydrates to suppress anaphylaxis in mice - PubMed
2 hours ago
- #anaphylaxis
- #carbohydrate metabolism
- #gut microbiome
- Acarbose, an antidiabetic α-glucosidase inhibitor, redirects gut microbiome dietary carbohydrate metabolism to suppress mast-cell-dependent anaphylaxis in mice.
- Enhanced carbohydrate availability promotes proliferation of Parabacteroides distasonis in the gut, increasing succinate levels and altering microbial respiration, independently of adaptive immune responses.
- Succinate is identified as a key effector, directly suppressing systemic anaphylaxis and mast cell degranulation in vitro.
- Human cohort analysis shows lower anaphylaxis incidence in patients treated with α-glucosidase inhibitors, linking dietary carbohydrate metabolism to systemic immune regulation via gut microbiota.