Hepatic SNHG9 links gut microbiota to liver protection in drug-induced liver injury - PubMed
3 hours ago
- #gut-liver axis
- #drug-induced liver injury
- #long non-coding RNA
- Hepatic lncRNA SNHG9 links gut microbiota to protection against acetaminophen-induced liver injury.
- SNHG9 upregulation activates the MAS receptor, enhancing autophagy to clear cellular damage.
- SNHG9 binds to IMP2, inhibiting MYC translation, which otherwise represses MAS1 gene expression.
- Gut microbiota, via metabolite HMB, regulates hepatic SNHG9 expression, attenuating liver injury.
- Supplementation with HMB or HMB-producing microbes induces SNHG9 and protects against drug-induced liver injury.