Breastfeeding shapes a unique tumor-immune landscape in pregnancy-associated breast cancer from GEICAM-EMBARCAM study - PubMed
3 hours ago
- #Pregnancy-Associated
- #Breast Cancer
- #Immune Landscape
- Pregnancy-associated breast cancer (PABC) is aggressive and poorly understood.
- The study analyzed 57 PABC patients and 49 controls using gene expression and immune profiling.
- All PABC cases showed increased proliferation and impaired DNA repair.
- Breastfeeding patients had a distinct immune-inflamed profile with elevated CD8 T-cells and TIGIT checkpoint.
- Lactation shapes tumor immunity, highlighting potential therapeutic avenues.