Perivascular adipose tissue modulates aortic reactivity in Marfan syndrome mice in a sex- and region-specific manner: Redox-dependent anticontractile effects in the female ascending aorta - PubMed
3 hours ago
- #Marfan syndrome
- #Perivascular adipose tissue
- #Redox signaling
- PVAT regulates aortic reactivity in Marfan syndrome mice differently by sex and aortic region.
- In female ascending aorta, PVAT reduces contractions via redox pathways involving NOX4 and iNOS.
- Anticontractile effect in females is lost with aging but persists without endothelium.
- Catalase and FeTPPS block the effect, implicating H₂O₂ and peroxynitrite signaling.
- MFS PVAT shows increased oxidative-nitrosative stress without lipid or protein structural changes.
- PVAT emerges as a potential therapeutic target for aortopathy in Marfan syndrome.