Unraveling the roles of fibroblast activation protein‑positive cancer‑associated fibroblasts in cancer: From mechanisms to therapy (Review) - PubMed
4 hours ago
- #tumor microenvironment
- #cancer-associated fibroblasts
- #FAP-targeted therapy
- Fibroblast activation protein-positive cancer-associated fibroblasts (FAP+ CAFs) are a major subtype in various cancers such as breast, lung, and pancreatic cancer.
- FAP+ CAFs play crucial roles in tumor progression through extracellular matrix organization, tumor expansion, and immunomodulation within the tumor microenvironment.
- Despite their significance, limited understanding of FAP+ CAF biology hinders their clinical application in diagnostics and therapy.
- This review provides a framework to advance FAP+ CAF-targeted strategies for cancer diagnosis and treatment.