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Supercharged ferritin nanocages enable universal cytosolic protein delivery - PubMed

2 hours ago
  • #protein delivery
  • #cytosolic delivery
  • #nanocages
  • Engineered supercharged ferritin nanocages with unnatural amino acids enable highly efficient intracellular protein delivery.
  • The nanocage system enhances cellular uptake, endosomal escape, and cytosolic release of protein cargoes through noncovalent complex formation.
  • Successful delivery of functional gene-editing tools and therapeutic antibodies demonstrated in female mouse models.
  • Supercharged interface engineering strategy advances next-generation cytosolic protein delivery platforms.