ENO1 couples HDAC1 to regulate histone lactylation and gene transcription - PubMed
3 hours ago
- #HDAC interactomes
- #histone lactylation
- #metabolic reprogramming
- Researchers developed BimPL, a proximity labeling strategy, to map endogenous HDAC interactomes in living cells.
- ENO1, a glycolytic enzyme, translocates to the nucleus and interacts with HDAC1 at chromatin, inhibiting HDAC1 activity via phosphoenolpyruvate (PEP).
- The ENO1-HDAC1 coupling promotes histone lysine lactylation (Kla), driving transcriptional reprogramming of oncogenes in hepatic malignancies.
- This study reveals a metabolic enzyme-orchestrated HDAC regulatory mechanism for histone lactylation, highlighting ENO1's moonlighting function in epigenetic reprogramming.