Reduced ULK1 links impaired autophagy and mitophagy to Alzheimer's disease pathology - PubMed
2 hours ago
- #Autophagy
- #ULK1
- #Alzheimer's Disease
- Reduced ULK1 levels observed in serum and cerebrospinal fluid during aging and Alzheimer's disease (AD) in human studies.
- ULK1 overexpression in AD mice enhances autophagic flux, reduces amyloid-β and tau pathology, delays cognitive decline, and improves mitochondrial quality.
- ULK1 upregulation increases autophagy and mitophagy, leading to higher cellular NAD+ levels, which deacetylate tau via SIRT1, reducing tauopathy.
- ULK1 activators show efficacy in inhibiting tauopathy in in vitro and C. elegans tau models, suggesting therapeutic potential.