Closed-loop iron chelate recycling via molecularly imprinted hydrogels suppresses ferroptosis - PubMed
4 hours ago
- #iron-chelate
- #ferroptosis
- #hydrogel
- Study introduces a hydrogel-based system with molecular 'memory' sites to selectively recognize and remove iron-chelate complexes.
- The system prevents local accumulation of iron-chelate complexes, which can cause secondary iron release, oxidative stress, and sustained tissue damage.
- In cell and animal models, the hydrogel restores iron balance, suppresses ferroptosis, and protects cartilage integrity.
- The approach improves efficiency and specificity compared to non-imprinted materials and offers a closed-loop strategy for regulating iron homeostasis.
- This framework is generalizable for treating iron-driven degenerative diseases, including osteoarthritis.