The VP1 protein of foot-and-mouth disease virus: Bridging pathogenicity and control strategies - PubMed
3 days ago
- #Vaccine development
- #Structural biology
- #FMDV VP1 protein
- VP1 protein of foot-and-mouth disease virus (FMDV) is crucial for pathogenicity and immune response.
- VP1's structure and functions aid in developing vaccines and control strategies.
- VP1 facilitates viral adsorption via RGD motif, immunomodulation via epitopes, replication, and immune evasion.
- Conformational dynamics of VP1's G-H loop, revealed by structural studies, are critical for integrin binding.
- VP1 genetic variation affects vaccine efficacy; advances in VP1-based vaccines and diagnostics are summarized.
- Current inactivated vaccines face challenges like limited cross-protection and cold-chain requirements.
- Future strategies include AI, cross-serotype antigen engineering, and genetic database mining for broad-spectrum vaccines and diagnostics.