Association of metabolic and inflammation vulnerabilities with systemic lupus erythematosus: a prospective UK Biobank study - PubMed
3 hours ago
- #Metabolic Vulnerability
- #UK Biobank Study
- #Systemic Lupus Erythematosus
- Higher metabolic vulnerability index (MVX) is associated with an increased risk of systemic lupus erythematosus (SLE), with a 44% higher risk per standard deviation increase.
- Participants in the highest tertile of MVX had an 89% increased risk of SLE compared to the lowest tertile, and MVX showed a stronger association than its sub-indices IVX and MMX.
- The association was particularly notable in females and showed a linear dose-response relationship, with risk thresholds identified for MVX, IVX, and MMX.
- Sensitivity analyses and competing risk models confirmed the robustness of the findings, supporting MVX as an independent risk factor for SLE.