Translational evidence for increased central amygdala IL-6 activity in alcohol dependence - PubMed
3 hours ago
- #alcohol dependence
- #neuroimmune
- #IL-6
- Chronic alcohol exposure activates IL-6 pathways in humans and rodents within the central amygdala, involving astrocytes, neurons, and microglia.
- IL-6 signaling inhibits GABAergic transmission in the central amygdala, linking neuroimmune changes to synaptic dysfunction in alcohol dependence.
- Systemic administration of an IL-6 receptor antibody reduced alcohol drinking in alcohol-dependent female mice, suggesting therapeutic potential for IL-6 inhibition in AUD.