O-GlcNAc modification regulates autophagy and apoptosis in endometriosis - PubMed
3 hours ago
- #mTOR pathway
- #O-GlcNAcylation
- #Endometriosis
- O-GlcNAcylation is elevated in endometriosis tissues, correlating with reduced autophagic function.
- Reducing O-GlcNAcylation in endometriotic cells inhibits proliferation and promotes autophagy and apoptosis, while increasing it has opposite effects.
- The mTOR pathway, potentially via O-GlcNAcylation of Raptor, mediates the regulation of autophagy and apoptosis by O-GlcNAcylation.
- In vivo suppression of O-GlcNAcylation reduces ectopic lesion growth and enhances autophagy and apoptosis in endometriosis.