Long-Term Outcomes After Ischemic Stroke Across Atrial Fibrillation Phenotypes Defined by Detection Timing and Prior Anticoagulation Status - PubMed
4 hours ago
- #Ischemic Stroke
- #Atrial Fibrillation
- #Anticoagulation
- The study compared long-term outcomes in ischemic stroke patients across three atrial fibrillation (AF) phenotypes: AF detected after stroke (AFDAS), AF complicated by stroke without prior anticoagulation (OAC-naive AF), and AF with stroke despite prior anticoagulation (AFIDA).
- Patients with AFIDA had the highest 5-year cumulative incidence of recurrent stroke/systemic embolism (18.6%) and an increased risk of heart failure hospitalization compared to OAC-naive AF.
- AFDAS was associated with the lowest 5-year cumulative incidence of recurrent stroke/SE (10.5%) and a lower risk compared to OAC-naive AF.
- The findings suggest that AF phenotypes, defined by detection timing and anticoagulation status, have heterogeneous prognoses, indicating a need for tailored secondary prevention strategies.