Parasite-specific essential bromodomain protein TgBDP4 is a key epigenetic reader and a potential drug target for the parasite Toxoplasma gondii - PubMed
3 days ago
- #Toxoplasma gondii
- #drug target
- #epigenetic regulation
- TgBDP4 is an essential bromodomain protein in Toxoplasma gondii that functions as an epigenetic reader of histone acetylation.
- TgBDP4 is crucial for parasite survival in vitro and in vivo, as shown by conditional knockdown studies.
- The bromodomain inhibitor I-BRD9 potently inhibits TgBDP4 and blocks parasite replication, extending survival in infected mice.
- TgBDP4 interacts with acetylated histone H3 and RNA polymerase II-CTD to regulate gene expression.
- The study identifies TgBDP4 as a promising drug target for treating toxoplasmosis due to its parasite-specific nature.