Dectin-1 signaling promotes Galectin-3 shedding and expansion of immunosuppressive CD71+ erythroid cells in breast cancer - PubMed
5 hours ago
- #Breast Cancer
- #Immunosuppression
- #CD71+ Erythroid Cells
- Curdlan worsens triple-negative breast cancer (TNBC) progression by expanding immunosuppressive CD71+ erythroid cells (CECs).
- Dectin-1 signaling induced by curdlan promotes Galectin-3 (Gal-3) shedding from CD11b+ cells, leading to Gal-3 deposition on CECs.
- Gal-3+ CECs co-express PD-L1 and Dectin-1, and PD-L1 blockade reduces these cells, suppresses extramedullary erythropoiesis, and induces tumor regression.
- scRNAseq data confirm the presence of Gal-3+ CECs in human bone marrow, highlighting their role in the immunosuppressive tumor microenvironment.