Understanding the Therapeutic Potential of PD-1 Agonism in Inflammatory and Autoimmune Disorders - PubMed
2 hours ago
- #PD-1 agonism
- #immunotherapy
- #autoimmune disorders
- The review focuses on harnessing PD-1 agonism to restore immune tolerance in autoimmune diseases.
- It analyzes four strategies for inducing PD-1 signaling: receptor dimerization, membrane-proximal epitope binding, affinity modulation, and Fcγ-receptor crosslinking.
- Optimal agonism may involve low-affinity antibodies targeting membrane-proximal epitopes to preserve natural signaling dynamics.
- The work aims to bridge knowledge gaps and guide development of next-generation immunotherapies for autoimmunity.