Testican-1 activates Wnt/β-Catenin signaling to drive colorectal cancer progression - PubMed
4 hours ago
- #Wnt Signaling
- #Testican-1
- #Colorectal Cancer
- Testican-1 (SPOCK1) activates Wnt/β-catenin signaling to promote colorectal cancer (CRC) progression.
- High SPOCK1 expression predicts poor prognosis and reduced survival after chemotherapy in CRC patients.
- Testican-1 modulates Wnt/β-catenin activity: downregulation inhibits β-catenin nuclear translocation and transcription, while overexpression enhances it.
- The pro-tumorigenic effect of Testican-1 is reversed by Wnt pathway inhibitors, confirming its dependence on Wnt activation.
- In vivo xenograft models and patient-derived organoids show increased growth and β-catenin nuclear localization with Testican-1 overexpression.
- Testican-1 overexpression enriches Wnt/β-catenin pathways and pro-tumorigenic pathways like c-Myc and oxidative phosphorylation.
- Testican-1 is linked to tumor microenvironment remodeling, featuring desmoplastic characteristics.
- The Testican-1/Wnt/β-catenin axis is identified as a key driver of CRC tumorigenesis and a potential therapeutic target.