Norovirus-specific monoclonal antibodies that block histo-blood group antigen binding isolated from healthy donors - PubMed
3 hours ago
- #Norovirus
- #LIBRA-seq
- #Monoclonal Antibodies
- Noroviruses cause acute gastroenteritis, lacking licensed vaccines or antivirals due to genetic diversity and limited cross-protective immunity.
- LIBRA-seq identified norovirus-specific B cells from healthy donors' blood, leading to 25 monoclonal antibodies with varying binding breadth across genotypes.
- Some antibodies broadly inhibit virus attachment to histo-blood group antigens (HBGAs), while others are genotype-restricted, revealing diverse functional responses.
- This approach helps understand natural immunity and provides tools for vaccine and therapeutic development against noroviruses.