Gut-derived bacterial extracellular vesicles: the microbial dark matter contributing to host inflammation and cardiometabolic disease - PubMed
4 hours ago
- #gut microbiota
- #extracellular vesicles
- #cardiometabolic disease
- Gut-derived bacterial extracellular vesicles (BEVs) play a role in host inflammation and cardiometabolic diseases (CMDs).
- BEVs are secreted by both gram-positive and gram-negative bacteria, carrying proteins, lipids, nucleic acids, and PAMPs.
- These vesicles can cross intestinal barriers, spread systemically, and accumulate in cardiometabolic tissues, affecting inflammation, insulin sensitivity, and organ function.
- BEVs interact with host pattern recognition receptors (PRRs) to modulate immune and metabolic responses.
- The review discusses BEVs as potential diagnostic biomarkers and therapeutic vectors for CMDs, along with technologies for their characterization.