Dietary yacon concentrate reshapes microbial-metabolite crosstalk to inhibit colorectal cancer - PubMed
4 hours ago
- #Gut Microbiota
- #Yacon Concentrate
- #Colorectal Cancer
- Yacon concentrate is rich in fructan, phenolic compounds, and flavonoids, with nutritional and antioxidant properties.
- In mouse models, yacon concentrate reduced colitis symptoms and suppressed colorectal tumor growth and incidence.
- Yacon supplementation enriched beneficial gut bacteria, inhibited immunotherapy-resistant bacteria, and boosted energy and short-chain fatty acid metabolism.
- Transplanting microbiota from yacon-treated samples into mice improved the tumor microenvironment and inhibited tumor growth.
- The study suggests yacon concentrate modulates the gut microbiota-metabolome axis, supporting its potential for colitis and colorectal cancer prevention and adjunctive treatment.