Peripheral nerve remodeling in the tumor microenvironment: neuro-immune crosstalk, molecular mechanisms, and precision therapeutic - PubMed
3 hours ago
- #Cancer Therapeutics
- #Neuro-Immune Crosstalk
- #Tumor Microenvironment
- The nervous system within the tumor microenvironment influences tumor development and metastasis, while tumors remodel neural structures to support their growth.
- Neuro-immune crosstalk involves interactions between neural cells, immune cells, and cancer cells, including Schwann cells presenting antigens and signaling with immune cells.
- Molecular mechanisms include sympathetic norepinephrine promoting T cell exhaustion and parasympathetic acetylcholine suppressing immune responses via α7 nicotinic receptors.
- Immune cell-derived neurotrophins like NGF and BDNF create feedback loops that enhance tumor-neural-immune interactions and immune evasion.
- Precision therapeutic strategies target this axis, such as β-adrenergic blockers, neurotrophin inhibition, denervation, and combinations with immunotherapy.