TPPP/p25 amyloid seeding activity as a specific biomarker for multiple system atrophy - PubMed
3 hours ago
- #Amyloid Seeding
- #Neurodegenerative Diseases
- #Biomarker
- TPPP/p25 amyloid seeding activity serves as a specific cerebrospinal fluid (CSF) biomarker for multiple system atrophy (MSA), improving diagnostic specificity over α-synuclein.
- A seed amplification assay using a minimized CORE (miniCORE) monomer can detect TPPP/p25 amyloid seeds in CSF, effectively differentiating MSA from Parkinson's disease and other neurodegenerative conditions.
- This breakthrough leverages the structural insights that TPPP/p25's core domain undergoes conformational changes to form amyloids, which are detectable in biofluids, offering a promising diagnostic tool for synucleinopathies.