Universal conditional knockout approach to multiple species, from fish to human induced pluripotent stem cells - PubMed
2 hours ago
- #gene knockout
- #functional genomics
- #vertebrate models
- A universal conditional knockout method using a Short Conditional intrON (SCON) cassette is applicable across vertebrate species.
- The SCON system enables efficient gene inactivation in zebrafish, human iPSCs, and organoids, overcoming lethality issues.
- A web-based GenPos-SCON database supports conditional knockout design for over 300 vertebrate species, accelerating functional studies.