APOE ε4 and amyloid status moderate the associations between sleep, physical activity, and tau-PET burden in cognitively unimpaired older adults - PubMed
3 hours ago
- #sleep
- #Alzheimer's disease
- #physical activity
- Greater wake after sleep onset (WASO) is linked to higher tau burden in APOE ε4 carriers and amyloid beta (Aβ)-positive individuals.
- Total volume of physical activity (TVPA) is associated with higher tau burden in Aβ-positive individuals but lower tau burden in Aβ-negative individuals.
- Associations between sleep, physical activity, and tau pathology vary based on genetic risk (APOE ε4) and amyloid status, emphasizing the need for risk stratification in Alzheimer's disease research.