Changes in arterial stiffness under blood pressure control are independently associated with cognitive impairment: The Systolic Blood Pressure Intervention Trial (SPRINT) - PubMed
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- Intensive blood pressure control over 3 years reduced load-dependent arterial stiffness (LD-PWV).
- This reduction in LD-PWV was associated with a 21% lower risk of cognitive impairment over a 10-year follow-up period.
- Total arterial stiffness (T-PWV) and structural stiffness (S-PWV) continued to increase regardless of blood pressure control.
- Each 1 m/s increase in T-PWV or S-PWV was linked to an 11–12% higher risk of cognitive impairment.