Multi-Omics Profiling Reveals Immunomodulatory and Pro-Regenerative Effects of a Graphene Oxide-Collagen Scaffold in Massive Rotator Cuff Tears - PubMed
3 hours ago
- #regenerative medicine
- #tissue engineering
- #biomaterials
- Developed a graphene oxide (GO)-engineered porcine type I collagen scaffold (GO/Col) for treating massive rotator cuff tears.
- GO incorporation improved scaffold stability, wettability, biocompatibility, stem cell adhesion, proliferation, and differentiation.
- GO/Col scaffolds promoted a reparative, anti-inflammatory macrophage phenotype and enhanced tendon-bone regeneration in a rat model.
- Integrated multi-omics analyses revealed GO-mediated modulation of immune regulation, stem cell differentiation, and tissue regeneration pathways.
- GO/Col scaffolds activated pro-osteogenic/chondrogenic and anti-inflammatory pathways while downregulating adipogenic and pro-inflammatory ones.
- The study supports GO/Col scaffolds as a bioactive tissue-engineering strategy for chronic MRCT repair.