Obesity Management Pharmacotherapies and Lifestyle Treatment for Pediatric Obesity Management: A Systematic Review and Network Meta-Analysis - PubMed
4 hours ago
- #Pediatric Obesity
- #Lifestyle Treatment
- #Pharmacotherapy
- This systematic review and network meta-analysis compares pharmacotherapies, lifestyle treatments, and their combinations for managing pediatric obesity.
- Combined treatments of pharmacotherapy and lifestyle therapy showed the greatest efficacy in reducing BMI, BMI z score, waist circumference, fat mass, and lean mass.
- Semaglutide plus counseling was associated with the largest reductions in BMI and BMI z score, though based on limited studies.
- All pharmacological treatments were more effective when paired with lifestyle treatment compared to medications alone.
- Health behavior and lifestyle treatment (HBLT) monotherapy also resulted in substantial decreases in BMI and BMI z score versus control.
- The findings emphasize that combined therapy yields the greatest short-term weight reduction, with HBLT being an indispensable component of effective weight management.
- Long-term sustainability and safety of these treatments require further monitoring.