Bisphenol A Induces Osteoporosis by Targeting LAMA4 and OLR1: Novel Insights into Environmental Bone Toxicity - PubMed
2 hours ago
- #osteoporosis
- #endocrine disruptors
- #bone toxicity
- Bisphenol A (BPA) exposure is linked to osteoporosis, with molecular targets and mechanisms identified.
- Multi-omics analyses reveal dysregulation of genes like LAMA4 (upregulated) and OLR1 (downregulated) in bone tissue and PBMCs.
- Non-cytotoxic BPA inhibits osteogenic differentiation in BMSCs, with LAMA4 and OLR1 showing responsive expression changes.
- Single-cell RNA sequencing shows LAMA4 enrichment in BMSCs, affecting intercellular communication.
- Findings highlight LAMA4 and OLR1 as key targets for BPA-induced bone toxicity, supporting skeletal risk assessment.