MAPK/ERK signaling regulates H3K9me3 heterochromatin reorganization to confer mesendoderm developmental competence - PubMed
3 hours ago
- #Epigenetics
- #Stem Cell Differentiation
- #MAPK/ERK Signaling
- MAPK/ERK signaling reorganizes H3K9me3-marked facultative heterochromatin during human pluripotent stem cell differentiation into mesendoderm, but not into neural ectoderm.
- Phosphorylated-ERK shows a reciprocal genomic pattern with H3K9me3, and MAPK/ERK inhibition leads to ectopic H3K9me3 accumulation.
- Proper H3K9me3 domain establishment represses off-target genes and supports lineage-specific gene activation, revealing how signaling shapes the epigenetic landscape for developmental competence.