MoCox6 is a potential fungicide target regulating mitophagy in magnaporthe oryzae - PubMed
2 hours ago
- #fungicide target
- #MoCox6
- #mitophagy
- MoCox6, an inner mitochondrial membrane protein in Magnaporthe oryzae, regulates mitophagy by interacting with cytosolic MoAtg5 and MoAtg14 upon mitochondrial damage.
- MoSirt5 desuccinylates MoCox6 at K144, weakening its interactions and restraining mitophagic flux, with Asp95 at the interface coupling mitochondrial metabolism to mitophagy.
- A high-throughput virtual screen targeting Asp95 in MoCox6 identified Pan-RAS-IN-1, a small molecule that suppresses rice blast and shows broad-spectrum antifungal activity.
- These findings highlight MoCox6 as a key regulator linking succinylation to mitochondrial turnover and identify mitochondrial quality control as a potential fungicide target.