The impact of gut microbiota and metabolite-driven immune cell spatiotemporal dynamics on tumors - PubMed
an hour ago
- #gut microbiota
- #immune cells
- #tumor microenvironment
- The immune response is crucial for eliminating tumor cells, with growing focus on the spatiotemporal dynamics of immune cells across time, space, and function.
- The gut microbiota, as a major part of the human microbiome, influences tumor initiation and progression, with its metabolites driving immune cell activation and remodeling within the tumor microenvironment (TME).
- This review examines how gut microbiota and metabolites affect anti-tumor immunity and the impact of immune cell dynamics on tumors, proposing new research strategies like the 'gut microbiota-immune cell dynamic monitoring model' and 'organoid-microbe co-culture platform'.
- The work aims to provide a theoretical foundation for understanding underlying mechanisms and developing innovative therapeutic approaches, with no declared conflicts of interest.